AnimalScience & Tecgnology

动物科学系

沈栩


沈栩· 广东饶平人 博士 副研究员  

研究方向:动物遗传育种与繁殖

功能基因组学

Email: Shenxu@zhku.edu.cn


学习经历

20019~20056:华南农业大学  动物科学 农学学士

20059~20086:华南农业大学  动物遗传育种与繁殖  农学硕士

20089~20116:华南农业大学  动物遗传育种与繁殖  农学博士


工作经历

201110~201410:中国科学院北京基因组研究所   博士后

201410~20196:中山大学 实验工程人员

20197~202012月:仲恺农业工程学院 讲师

20211~至今  :仲恺农业工程学院  副研究员


主要研究领域:

水禽繁殖性状分子遗传机制解析及表观遗传调控机理研究。


承担科研项目情况

1. 广东省自然科学基金面上项目:光周期调控鹅垂体PTthyrotroph细胞季节性分泌TSH的分子机制,资助号:2021A151501078110万元,2021/01-2023/12,主持;

2. 国家自然科学基金青年项目:转录因子NR5A1介导的多基因调控网络影响鸡就巢性状的遗传和进化机制,资助号:3130101023万元,2013/01-2016/12,主持;

3. 中国博士后科学基金面上项目:转录因子NR5A1Egr1参与家鸡繁殖性状调控的分子机制,资助号:2012M5203595万元,2012/09-2013/10,主持。

4. 国家自然科学基金面上项目:极端环境下红树植物小RNA表观遗传调控转座子的进化基因组学研究,资助号,31770246, 60万元,2018.1~2021.12,参与;

5. 国家自然科学基金面上项目:极端环境下红树植物小RNA表观遗传调控转座子的进化基因组学研究,资助号,31770246, 60万元,2018.1~2021.12,参与;

6. 国家自然科学基金青年项目:miRNA介导基因调控网络的进化及其对种间表型差异的影响,批准号:3180108127万元,2019.01-2021.12,参与;

7. 国家自然科学基金重点项目:从多基因互作及miRNA调控网络水平研究生殖隔离的遗传机制,资助号:31730046, 303万元,2018.1~2022.12,参与;


研究论文

(#并列第一作者 *共同通讯)

1Xu Shen, XueBai, Chenlong Luo, Danli Jiang, Xiujin Li, Xumeng Zhang, Yunbo Tian, Yunmao Huang. Quantitative proteomic analysis of chicken serum reveals key proteins affecting follicle development during reproductive phase transitions. Poultry Science, 2021,100(1):325-333. doi: 10.1016/j.psj.2020.09.058

2) Yuezheng Zhang#, Yawei Li#, Tao Li#, Xu Shen#, Tianqi Zhu, Yong Tao, Xueying Li, Di Wang,  Qin Ma, Zheng Hu, Jialin Liu, Jue Ruan, Jun Cai, Hurng-Yi Wang, Xuemei Lu. Genetic load and potential mutational meltdown in cancer cell populations.Molecular Biology and Evolution, 2019, 1;36(3):541-552. doi: 10.1093/molbev/msy231

3Guangan Lu, Yixin Zhao, Hao Yang, Ao Lan, Suhua Shi, Zhongqi Liufu, Yao Huang, Tian Tang, Jin Xu, Xu Shen*, Chung-I Wu*. Death of new microRNA genes in Drosophila via gradual loss of fitness advantages. Genome Research. 2018, 28(9):1309-1318.

4Shen XuBai XueXu JinZhou MinXu HaipinNie QinghuaLu Xuemei Zhang Xiquan . Transcriptome sequencing reveals genetic mechanisms underlying the transition between the laying and brooding phases and gene expression changes associated with divergent reproductive phenotypes in chickens. Mol Biol Rep, 2016,43(9)977~989.

5Shen X , Zeng H, Xie L, He J, Li J, Xie X, Luo C, Xu H, Zhou M, Nie Q, Zhang X, The GTPase activating Rap/RanGAP domain-like 1 gene is associated with chicken reproductive traits. PLoS One. 2012,7(4):e33851.

6Xu H # , Shen X # (Contributed), Zhou M, Fang M, Zeng H, Nie Q, Zhang X. The genetic effects of the dopamine D1 receptor gene on chicken egg production and broodiness traits. BMC Genet. 2010, 11:17.

7) Chen Qingjian, He Ziwen, Lan Ao, Shen Xu, Wen Haijun, Wu Chung-I. Molecular Evolution in Large Steps—Codon Substitutions under Positive Selection. Mol Biol Evol.2019.msz108. doi: 10.1093/molbev/msz108

8) Chen Bingjie, Shi Zongkun, Chen Qingjian, Shen Xu, Shibata Darryl, Wen Haijun, Wu Chung-I. Tumorigenesis as the Paradigm of Quasi-neutral Molecular Evolution. Mol Biol Evol.2019, 36(7):1430-1441

9Zhao Yixin, Shen Xu, Tang Tian, Wu Chung-I. Weak regulation of many targets is cumulatively powerful- a reply to Seitz on microRNA functionality. Mol Biol Evol. 2019, 36(7):1598-1599. doi: 10.1093/molbev/msz055.

10Zhao Y, Lin P, Liufu Z, Yang H, Lyu Y, Shen X, Wu CI, Tang T. Regulation of Large Number of Weak Targets-New Insights from Twin-microRNAs. Genome Biol Evol. 2018. 10(5):1255-1264

11) Yang Y, Guo W, Shen X, Li J, Yang S, Chen S, He Z, Zhou R, Shi S. Identification and characterization of evolutionarily conserved alternative splicing events in a mangrove genus Sonneratia. Sci Rep. 2018, 8(1):4425

12Zhao Yixin, Shen Xu, Tang Tian, Wu Chung-I. Weak Regulation of Many Targets Is Cumulatively Powerful-An Evolutionary Perspective on microRNA Functionality, Mol. Biol .Evol. 2017, 34(12):3041-3046

13Jianhua Huang, Yushuai Wang, Wenwen Liu, Xu Shen, Qiang Fan, Shuguang Jian, Tian Tang. EARE-1, a Transcriptionally Active Ty1/Copia-Like Retrotransposon Has Colonized the Genome of Excoecaria agallocha through Horizontal Transfer, Front Plant Sci . 2017,8:45

14) Liu W, Wang Y, Shen X, Tang T. Isolation, characterization and marker utility of KCRE1, a transcriptionally active Ty1/copia retrotransposon from Kandelia candel. Mol Genet Genomics . 2016, 291(6):2031-2042.

15) Wen M, Lin X, Xie M, Wang Y, Shen X, Liufu Z, Wu CI, Shi S, Tang T. Small RNA transcriptomes of mangroves evolve adaptively in extreme environments. Sci Rep. 2016, 6:27551

16) Luo C, Shen X, Rao Y, Xu H, Tang J, Sun L, Nie Q, Zhang X. Differences of Z chromosome and genomic expression between early- and late-feathering chickens. Mol Biol Rep, 2012, 39(5):6283-8

17) Xu HP, Shen X, Zhou M, Luo CL, Kang L, Liang Y, Zeng H, Nie QH, Zhang DX, Zhang XQ. The dopamine D2 receptor gene polymorphisms associated with chicken broodiness. Poult Sci, 2010, 89(3):428-38

18) Rao Y, Shen X, Xia M, Luo C, Nie Q, Zhang D, Zhang X. SNP mapping of QTL affecting growth and fatness on chicken GGA1. Genet Sel Evol, 2007, 39(5):569-82

19) Rao YS, Liang Y, Xia MN, Shen X, Du YJ, Luo CG, Nie QH, Zeng H, Zhang XQ. Extent of linkage disequilibrium in wild and domestic chicken populations. Hereditas, 2008, 145(5):251-77      

20) Nie Q, Hu Y, Xie L, Zhang C, Shen X, Zhang X. Identification and characterization of adipose triglyceride lipase (ATGL) gene in birds. Mol Biol Rep, 2010, 37(7):3487-938

21) Nie QH, Fang MX, Xie L, Shen X, Liu J, Luo ZP, Shi JJ, Zhang XQ. Associations of ATGL  gene polymorphisms with chicken growth and fat traits. J Appl Genet. 2010, 51(2): 185-91


发明专利

张细权、沈栩、曾华、谢亮. 与鸡 300 日龄产蛋量相关的 GARNL1 基因上的位点及其应用. 2012.12. 中国. ZL 2010 10280382.X

阮珏,王开乐,沈栩,吕雪梅,吴仲义. 一种DNA扩增方法. 2019.05.17. 中国,ZL 2014 10448896.X